@font-face{font-family:Manrope;src:url('/assets/manrope-bold.ttf') format('truetype');font-style:normal;font-weight:700 800;font-display:swap}
@font-face{font-family:'DM Sans';src:url('/assets/dm-sans.ttf') format('truetype');font-style:normal;font-weight:400;font-display:swap}
:root{--paper:#f5f3ec;--ink:#223e35;--muted:#54665e;--orange:#c64a28;--peach:#ecb59f;--line:#cdd0c4;--green:#dfe6d7;--white:#fffef8;--font-body:'DM Sans',sans-serif;--font-heading:Manrope,sans-serif}
*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:30px}body{margin:0;background:var(--paper);color:var(--ink);font:16px/1.6 var(--font-body);-webkit-font-smoothing:antialiased}::selection{background:var(--peach);color:var(--ink)}a{color:inherit;text-decoration-thickness:1px;text-underline-offset:4px}button,input,select{font:inherit}button,a,input,select{-webkit-tap-highlight-color:transparent}button{cursor:pointer}input,select{caret-color:var(--orange)}:focus-visible{outline:3px solid var(--orange);outline-offset:5px}a,button{touch-action:manipulation}img,svg{display:block;max-width:100%}svg{width:24px;height:24px;flex-shrink:0}h1,h2,h3,p{margin:0}h1,h2,h3{font-family:var(--font-heading);font-weight:800;line-height:1.12;letter-spacing:-.035em;text-wrap:balance}p{text-wrap:pretty}[hidden]{display:none!important}.shell{width:min(1280px,calc(100% - 112px));margin-inline:auto}.muted{color:var(--muted)}.button{display:inline-flex;align-items:center;justify-content:center;gap:28px;min-height:52px;padding:14px 24px;border:0;border-radius:5px;background:var(--ink);color:var(--white);font-size:14px;font-weight:700;text-decoration:none;transition:background .2s,transform .2s}.button:hover{background:#38594c;transform:translateY(-2px)}.button-small{font-size:13px;min-height:46px;padding:11px 20px;gap:19px}.button-orange{background:var(--orange)}.button-orange:hover{background:#a93a1d}.button:disabled{opacity:.6;cursor:wait;transform:none}.text-link,.read-link{display:inline-flex;align-items:center;gap:17px;font-size:14px;font-weight:700;text-decoration:none}.text-link:hover,.article-link:hover .read-link{color:var(--orange)}.text-link svg{transition:transform .2s}.text-link:hover svg{transform:translateX(4px)}.skip-link{position:absolute;left:20px;top:-100px;z-index:30;padding:12px;background:var(--ink);color:white}.skip-link:focus{top:10px}.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.honey{display:none}
.header{border-bottom:1px solid var(--line)}.header-inner{display:flex;align-items:center;justify-content:space-between;gap:32px;min-height:111px}.brand{display:inline-flex;align-items:center;gap:12px;text-decoration:none;font-family:var(--font-heading);font-weight:800;font-size:21px;letter-spacing:-.04em;line-height:1.04;flex-shrink:0}.logo-bottom{display:block}.logo-period{color:var(--orange)}.logo-mark{position:relative;width:30px;height:42px;display:flex;align-items:center;gap:4px}.logo-mark i{display:block;width:6px;border-radius:8px;background:var(--orange);height:24px;transform:rotate(25deg)}.logo-mark i:nth-child(2){height:40px}.logo-mark i:nth-child(3){height:24px}nav{display:flex;gap:34px}nav a{font-size:13px;text-decoration:none}nav a:hover{text-decoration:underline}.menu-button{display:none}
.hero{padding-top:69px;padding-bottom:50px}.hero-heading{display:grid;grid-template-columns:1.2fr 1fr;align-items:end;gap:60px;margin-bottom:54px}.hero h1{font-size:clamp(64px,7.5vw,96px);line-height:1.02}.hero h1 span{color:var(--orange)}.hero-intro{max-width:390px;padding-bottom:4px}.hero-intro>p:first-child{font-size:23px;line-height:1.4;letter-spacing:-.02em}.hero-intro .muted{font-size:15px;margin-top:16px;margin-bottom:23px;max-width:350px}.hero-feature{display:grid;grid-template-columns:1.15fr 1fr;min-height:370px;background:var(--green);overflow:hidden;border-radius:8px}.feature-image{position:relative;display:block;overflow:hidden;min-height:370px}.feature-image img{width:100%;height:100%;position:absolute;object-fit:cover;filter:saturate(.6);transition:transform .7s cubic-bezier(.2,.8,.2,1)}.feature-image:hover img{transform:scale(1.035)}.image-caption{position:absolute;bottom:20px;left:22px;font-size:11px;letter-spacing:.02em;color:var(--white);background:var(--ink);padding:7px 12px;border-radius:3px}.feature-copy{padding:36px 40px 28px;display:flex;flex-direction:column}.feature-label{display:flex;align-items:center;gap:8px;font-size:11px;order:3;margin-top:21px}.small-dot{width:6px;height:6px;border-radius:50%;background:var(--orange)}.feature-copy h2{font-size:34px;max-width:470px}.feature-copy h2 a{text-decoration:none}.feature-copy h2 a:hover{text-decoration:underline}.feature-copy>p{font-size:14px;line-height:1.65;margin-top:17px;max-width:360px}.round-link{display:flex;align-items:center;justify-content:space-between;gap:12px;font-size:12px;font-weight:700;text-decoration:none;margin-top:26px}.round-link .muted{font-size:11px;font-weight:400}.arrow-circle{display:grid;place-items:center;width:42px;height:42px;border:1px solid #9caa95;border-radius:50%;transition:background .2s}.round-link:hover .arrow-circle{background:var(--white)}.principles{border-block:1px solid var(--line)}.principles .shell{display:flex;align-items:center;justify-content:space-between;min-height:67px;gap:20px}.principles span{font-size:12px}.principles-last{display:flex;gap:13px;align-items:center}.principles-last svg{width:19px}
.reading-room{padding-top:80px;padding-bottom:80px}.section-heading{display:flex;align-items:end;justify-content:space-between;gap:30px}.section-heading h2{font-size:42px}.section-heading h2>span,.index-page h1>span{color:var(--orange)}.section-heading p{font-size:13px;color:var(--muted);padding-bottom:4px}.filters{display:flex;gap:10px;flex-wrap:wrap;margin:30px 0 36px}.filters button{min-height:40px;border:1px solid var(--line);border-radius:24px;background:transparent;color:var(--ink);padding:8px 17px;font-size:12px;transition:background .2s,color .2s}.filters button[aria-pressed=true]{background:var(--ink);border-color:var(--ink);color:var(--white)}.filters button:hover{border-color:var(--ink)}.article-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:24px}.article-card{min-width:0}.article-link{display:block;text-decoration:none}.article-art{height:193px;display:grid;place-items:center;overflow:hidden;border-radius:5px}.article-art svg{width:100%;height:100%;transition:transform .4s ease-out}.article-link:hover .article-art svg{transform:scale(1.06)}.molecule-art{background:#d4dcc9;color:#44644d}.recovery-art{background:#dfb49c;color:#774932}.metabolic-art{background:#dfdfc1;color:#626744}.skin-art{background:#dfc8bd;color:#815a46}.article-meta{display:flex;justify-content:space-between;gap:8px;font-size:10px;color:var(--muted);margin:17px 0 11px}.article-meta>span:first-child{font-weight:700;color:var(--orange)}.article-card h3{font-size:21px;line-height:1.25;letter-spacing:-.025em}.article-card p{font-size:12px;line-height:1.7;color:var(--muted);margin-top:12px}.read-link{font-size:11px;margin-top:17px;gap:12px}.read-link svg{width:18px}.approach{display:grid;grid-template-columns:1fr 1fr;gap:80px;padding-block:56px 65px;border-top:1px solid var(--line)}.approach h2{font-size:36px;max-width:460px}.approach .text-link{margin-top:23px}.approach-copy{max-width:470px}.approach-copy p{font-size:14px;color:var(--muted)}.approach-copy p+p{margin-top:16px}
.newsletter{background:var(--ink);color:var(--paper);padding-block:65px;scroll-margin-top:20px}.newsletter-layout{display:grid;grid-template-columns:1fr 1fr;gap:80px}.newsletter h2{font-size:42px;line-height:1.15}.newsletter-layout>div>p{margin-top:20px;font-size:14px;color:#d1dccf;max-width:365px}.newsletter-layout>div>.newsletter-note{margin-top:23px;font-size:11px;color:#c3d0bf}.field-row{display:grid;grid-template-columns:1fr 1.3fr;gap:17px}.field label,.privacy-form>label{display:block;font-size:12px;margin-bottom:9px}.field label span{color:#c3d0bf;font-size:10px}.field input{width:100%;min-width:0;background:transparent;color:var(--paper);border:1px solid #8a9c8c;border-radius:4px;padding:12px 14px;min-height:49px;font-size:13px}.field input::placeholder{color:#c3d0bf}.consent{display:flex;align-items:start;gap:11px;margin-top:19px;font-size:12px;line-height:1.65;color:#d1dccf;cursor:pointer}.consent input{flex-shrink:0;width:17px;height:17px;margin:3px 0 0;accent-color:var(--orange)}.consent a{color:var(--paper)}.capture-form>.button{margin-top:24px;min-width:210px}.form-status{font-size:13px;margin-top:12px;min-height:22px}.form-status.error{color:#ffc4ae}.privacy-form .form-status.error{color:#a63318}
footer{padding:44px 0 22px}.footer-top{display:grid;grid-template-columns:1fr 1fr 1fr;gap:30px;padding-bottom:36px}.footer-top>.brand{align-self:start;font-size:20px}.footer-top>p{font-size:14px;line-height:1.5}.footer-links{display:grid;grid-template-columns:1fr 1fr;gap:10px 20px;align-content:start}.footer-links a{font-size:10px;text-decoration:none}.footer-links a:hover{text-decoration:underline}.footer-bottom{border-top:1px solid var(--line);display:flex;gap:20px;justify-content:space-between;padding-top:19px;color:var(--muted);font-size:10px}
.article-shell,.page-shell{width:min(830px,calc(100% - 48px));margin:0 auto;padding-block:46px 80px}.back-link{display:inline-flex;align-items:center;gap:12px;text-decoration:none;font-size:12px;margin-bottom:36px}.back-link svg{transform:rotate(180deg);width:19px}.article-header h1,.page-shell>h1{font-size:clamp(38px,4.2vw,61px);line-height:1.12}.article-deck{font-size:19px;color:var(--muted);margin-top:23px;max-width:690px}.byline{font-size:11px;margin-top:23px;color:var(--muted);display:flex;gap:12px;flex-wrap:wrap}.article-shell>.article-art{height:300px;margin-top:32px}.article-body,.prose{max-width:69ch;margin-inline:auto}.article-body>section{margin-top:36px}.article-body h2,.prose h2{font-size:26px;margin-top:36px;margin-bottom:14px;line-height:1.2}.article-body p,.prose p{font-size:17px;line-height:1.85}.prose{margin-top:32px}.sources{padding-top:12px;border-top:1px solid var(--line)}.sources ul{list-style:none;padding:0}.sources a{display:inline-flex;align-items:center;gap:10px;font-size:14px}.sources p.muted{font-size:13px;margin:23px 0}.article-body>.text-link{margin-top:26px}.privacy-form{margin-top:24px}.privacy-form input,.privacy-form select{display:block;width:100%;border:1px solid #88978a;border-radius:4px;background:var(--white);min-height:48px;padding:12px;margin-bottom:19px;color:var(--ink)}.privacy-form .button{margin-top:4px}.index-page{padding-block:65px 80px}.index-page h1{font-size:clamp(48px,5vw,75px)}.index-intro{font-size:20px;color:var(--muted);margin:20px 0 48px}.index-list>a{display:flex;align-items:center;gap:30px;text-decoration:none;padding-block:28px;border-top:1px solid var(--line)}.index-list>a:last-child{border-bottom:1px solid var(--line)}.index-list h2{font-size:29px}.index-list p{font-size:14px;color:var(--muted);margin-top:8px}.index-list>a>span{margin-left:auto;font-size:12px;color:var(--orange)}.index-list>a:hover h2{text-decoration:underline;text-underline-offset:5px}.index-note{font-size:13px;color:var(--muted);margin-top:30px;max-width:600px}
@media(min-width:1000px){.hero-heading h1{animation:heading-arrive .8s cubic-bezier(.16,1,.3,1) both}@keyframes heading-arrive{from{transform:translateY(12px)}to{transform:translateY(0)}}}
@media(min-width:1600px){.hero{padding-top:82px}.hero-heading{margin-bottom:64px}}
@media(max-width:1100px){.shell{width:calc(100% - 64px)}nav{gap:21px}.header-inner{gap:20px}.hero-heading{gap:35px}.hero-intro>p:first-child{font-size:21px}.feature-copy{padding:29px}.feature-copy h2{font-size:29px}.article-grid{grid-template-columns:repeat(2,1fr);gap:36px 26px}.article-art{height:225px}.article-card h3{font-size:25px}.article-card p{font-size:14px}.article-meta{font-size:12px}.read-link{font-size:13px}.newsletter-layout{gap:45px}.newsletter h2{font-size:35px}.footer-links{gap:10px}.header-cta{padding:11px 14px;gap:12px}}
@media(max-width:760px){.shell{width:calc(100% - 40px)}.header-inner{min-height:88px;gap:16px;flex-wrap:wrap;position:relative}.brand{font-size:18px;gap:9px}.logo-mark{transform:scale(.85);transform-origin:left center;width:27px}.header-cta{margin-left:auto;min-height:41px;font-size:11px;padding:9px 12px;gap:7px}.header-cta svg{width:18px}.menu-button{display:flex;align-items:center;gap:7px;background:transparent;border:0;color:var(--ink);padding:10px 0;font-size:12px;min-height:44px;order:3}.menu-button svg{width:19px}nav{display:none;flex-basis:100%;order:4;flex-direction:column;gap:0;padding-bottom:15px}nav.is-open{display:flex}nav a{padding:11px 0;border-top:1px solid var(--line)}.hero{padding-top:42px;padding-bottom:30px}.hero-heading{grid-template-columns:1fr;gap:28px;margin-bottom:34px}.hero h1{font-size:76px;line-height:.99}.hero-intro{max-width:100%;padding:0}.hero-intro>p:first-child{font-size:20px}.hero-intro .muted{max-width:370px;margin-top:12px;margin-bottom:17px}.hero-feature{grid-template-columns:1fr}.feature-image{min-height:260px}.feature-copy{padding:27px}.feature-copy h2{font-size:30px;max-width:500px}.feature-copy>p{font-size:14px;max-width:440px}.round-link{margin-top:23px}.feature-label{margin-top:16px}.principles .shell{display:grid;grid-template-columns:1fr 1fr;gap:12px 20px;padding-block:20px}.principles span{font-size:10px}.principles-last svg{display:none}.reading-room{padding-block:45px}.section-heading{display:block}.section-heading h2{font-size:35px}.section-heading p{margin-top:10px}.filters{gap:7px;margin:23px 0 28px}.filters button{font-size:11px;padding-inline:13px;min-height:42px}.article-grid{gap:30px 18px}.article-art{height:155px}.article-card h3{font-size:21px}.article-card p{font-size:12px}.article-meta{font-size:10px;flex-wrap:wrap;margin-top:13px;gap:3px 10px}.read-link{font-size:11px;gap:8px}.approach{grid-template-columns:1fr;gap:25px;padding-block:38px}.approach h2{font-size:31px}.approach .text-link{margin-top:18px}.newsletter{padding-block:42px}.newsletter-layout{grid-template-columns:1fr;gap:29px}.newsletter h2{font-size:35px}.newsletter-layout>div>p{max-width:430px;margin-top:15px}.newsletter-layout>div>.newsletter-note{margin-top:16px}.field-row{gap:13px}.consent{font-size:11px}.capture-form>.button{width:100%;margin-top:20px}footer{padding-top:33px}.footer-top{grid-template-columns:1fr 1fr;gap:26px;padding-bottom:25px}.footer-top>p{font-size:12px;justify-self:end}.footer-links{grid-column:1/-1;grid-template-columns:repeat(2,1fr);gap:10px 26px}.footer-links a{font-size:12px;min-height:32px;display:flex;align-items:center}.footer-bottom{flex-direction:column;gap:9px;font-size:10px}.article-shell,.page-shell{padding-block:30px 50px}.article-header h1,.page-shell>h1{font-size:39px}.article-deck{font-size:17px}.article-shell>.article-art{height:220px}.article-body p,.prose p{font-size:16px}.byline{gap:7px;font-size:10px}.index-page{padding-block:44px}.index-page h1{font-size:48px}.index-intro{font-size:17px;margin-bottom:32px}.index-list>a{gap:14px;flex-wrap:wrap}.index-list>a>div{flex-basis:calc(100% - 40px)}.index-list>a>span{margin-left:0;order:3}.index-list h2{font-size:26px}.index-list p{font-size:13px}.index-list>a>svg{margin-left:auto}.index-note{font-size:12px}}
@media(max-width:380px){.hero h1{font-size:66px}.header-inner{gap:10px}.header-cta{font-size:10px;padding-inline:10px}.header-cta svg{display:none}.article-grid{grid-template-columns:1fr}.article-art{height:200px}.article-card h3{font-size:25px}.article-card p{font-size:14px}.field-row{grid-template-columns:1fr}.menu-button{font-size:11px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*::before,*::after{animation:none!important;transition:none!important}}

/* Reading and consent text retain accessible size and contrast at every breakpoint. */
.article-meta>span:first-child,.index-list>a>span{color:#b64022}
.article-meta,.read-link,.footer-links a,.footer-bottom,.feature-label,.image-caption,.round-link,.round-link .muted,.field label,.field label span,.newsletter-layout>div>.newsletter-note,.byline,.consent{font-size:12px}
.article-card p{font-size:14px}
.database-introduction{display:flex;justify-content:space-between;align-items:start;gap:35px;margin-top:-24px;margin-bottom:35px}.database-introduction>p{max-width:650px;color:var(--muted);font-size:16px}.database-introduction>.text-link{flex-shrink:0;margin-top:5px}.database-controls{display:grid;grid-template-columns:2fr 1fr 1fr;gap:20px;padding:25px;background:var(--green);border-radius:8px}.database-controls label{display:block;font-size:13px;margin-bottom:8px;font-weight:700}.database-controls input,.database-controls select{width:100%;min-width:0;border:1px solid #88978a;border-radius:4px;padding:12px;background:var(--white);color:var(--ink);min-height:48px;font-size:14px}.database-controls input::placeholder{color:var(--muted)}.database-results-bar{display:flex;justify-content:space-between;gap:18px;align-items:center;min-height:72px}.database-results-bar>p{font-size:13px;color:var(--muted)}.database-clear{border:0;background:transparent;color:var(--ink);text-decoration:underline;text-underline-offset:4px;font-size:13px;padding:10px}.compound-columns,.compound-row{display:grid;grid-template-columns:minmax(0,1fr) 155px 130px;gap:28px;align-items:center}.compound-columns{padding:12px 0;font-size:12px;color:var(--muted);border-bottom:1px solid var(--line)}.compound-row{padding:23px 0;border-bottom:1px solid var(--line)}.compound-row h2{font-size:25px;letter-spacing:-.025em;overflow-wrap:anywhere}.compound-aliases{font-size:13px;color:var(--muted);margin-top:7px;overflow-wrap:anywhere}.compound-category{font-size:12px;color:#b64022}.compound-source{font-size:13px;gap:9px}.compound-source svg{width:20px}.directory-empty{padding:38px 0}.directory-empty h2{font-size:28px}.directory-empty p{margin:14px 0 22px;color:var(--muted)}.database-provenance{max-width:74ch;margin-top:60px}.database-provenance h2,.database-reading>h2{font-size:32px;margin-bottom:21px}.database-provenance p{font-size:15px;line-height:1.8;color:var(--muted);margin-top:16px}.database-provenance>.text-link{margin-top:22px}.database-reading{margin-top:60px}.database-reading h3{font-size:25px}
@media(max-width:900px){.database-introduction{display:block}.database-introduction>.text-link{margin-top:20px}.database-controls{grid-template-columns:1fr 1fr;gap:18px}.database-search{grid-column:1/-1}.compound-columns,.compound-row{grid-template-columns:minmax(0,1fr) 125px 115px;gap:18px}}
@media(max-width:600px){.database-page h1{font-size:44px}.database-introduction{margin-top:-14px}.database-introduction>p{font-size:15px}.database-controls{padding:18px;gap:16px 12px}.database-controls select{font-size:13px;padding-inline:9px}.database-controls input{font-size:14px}.compound-columns{display:none}.compound-row{grid-template-columns:minmax(0,1fr) auto;gap:12px;padding:24px 0}.compound-row>div{grid-column:1/-1}.compound-row h2{font-size:25px}.compound-aliases{font-size:13px;line-height:1.7}.compound-category{grid-column:1}.compound-source{grid-column:2}.database-provenance,.database-reading{margin-top:42px}.database-provenance h2,.database-reading>h2{font-size:28px}.database-reading h3{font-size:22px}}